Major League DJz Throws Shade at 50 Cent Following His Weight Loss: “Ozempic Is That You”

• South African Amapiano duo Major League DJz recently made headlines on social media after throwing shade at 50 Cent
• The twins made fun of the American rapper's weight loss on their Twitter (X) page
• Many netizens flooded the comment section with their reactions to what Major League DJz said about 50 Cent

Bathong, South African Amapiano duo Major League DJz couldn't hold themselves as they made fun of the popular American rapper, 50 Cent.

Major League DJz threw shade at 50 Cent

On Sunday, 14 September 2025, the popular twins who have been questioned about their weight loss on social media recently threw shade at the American star 50 Cent following his weight loss.

Major League Djz reposted a video of the star skipping rope on their X (formerly Twitter) page and wrote:

"I’m guessing … Ozempic is that you?"

See the post below:

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Netizens reacted to Major League DJz throwing shade at 50 Cent

Shortly after the duo threw that previously showed off their lavish weight loss routine shade at the American rapper, many netizens flooded the comment section with their reactions. Here's what they had to say below:

@dikwekubanice said:

"Yeke ilala bra..the way you’re trying to convince us awudliwanga yi Ozempic, the more we find it suspicious."

@NtshepyK wrote:

"He did that liquid diet for a movie back then, so nothing new, he has been having a 6 pack all along. Lona leirile mathata."

@DebbieBloodmoon commented:

"Didn’t DJ Envy mention he was on Ozempic, allegedly? He got backlash a while ago. U competing on the scale of Ozempic backlash? Weird how u still triggered."

@BootyfulAfrica responded:

"Tony Yayo was literally on The ShayShay show talking about how 50 works out 3 times a day for this role. lol you guys know your days have never looked like that. Working out is something 50 has been doing forever."

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@wayne_mgwezane replied:

"Nah, bro, you’re trying too hard now. Are you telling me The Rock is also on Ozempic? Even when 50 Cent lost drastic weight to play a character who had cancer in a movie? What about Anathi ke? Stop playing."

@nomsashabanguf shared:

"Nina lost weight in 3 weeks...There's a huge difference between 50 Cent and you guys. Look at those physics and the jawbone, the arms, the chest. Unlike abanye ngathi baqoka 34 cups."

@NjekaModise tweeted:

"Guys, be honest, man, you went from 100 to 30 in a few days...weight loss doesn't work like that, if it worked like that ngabe everyone would be skinny, be realistic, gents."

Major League DJz call out Open Chats Podcast

Meanwhile, Major League DJz were one of the few celebrities who weighed in on the hurtful comments made by the Open Chats Podcast towards the coloured community, as reported by Briefly News.

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During the taping of one of their episodes for the YouTube channel, the Open Chats Podcast presenters made derogatory statements which divided South Africans. Major League DJz criticised podcasts as a whole, highlighting a growing trend of sensationalism and rage-baiting.

Source: Briefly News